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Women general observe brown, pinkish or red urine during menstruation or immediately after menstruation

Feel tired and need an energy boost

This dose falls within the effective clinical range while allowing room to increase if response is minimal

Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

However, many proposed mechanisms remain under investigation and are not fully characterized