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The figure also shows an acetylated lipoyllysine moiety, highlighting its role in acyl group transfer
More elegantly, the peptide itself can be redesigned for stability unnatural amino acids (like Aib), cyclization, D-amino acid substitutions, and PEGylation all make the molecule harder for proteases to cleave and can extend half-life
A further mechanistic consideration is whether the pomegranate extract may have influenced plasma TMAO concentrations partly through its effect on the absorption of L-carnitine in the small intestine, rather than solely through inhibition of microbial TMA production
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