When circulation diminishes, follicles receive less oxygen, fewer growth factors, and inadequate building blocks for keratin production
Activation of these proteins contributes to actin cytoskeleton remodeling and changes in cell migration behavior
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In these mechanisms of PGs, LTs, LXs, PAF, receptors play significant roles, therefore inhibitors or agonists of these receptors can exert therapeutic functions, and the therapeutic effects are proven in animal experiments ( Figure 3 )