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Not for use in diagnostic procedures
Initially, doses are given daily or weekly until levels normalize and maintained monthly afterward
These improvements were linked to changes in brain tissue, where certain genes involved in blood vessel growth and brain protection became more active, which may explain how healing happened
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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function
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