Entre los primeros estudios en los humanos podemos destacar los de Dragan y cols (1987, Physiologie 24: 13-8 y 231-4), con resultados positivos en atletas de lite al estudiar varios parmetros (son estudios realizados en Rumana antes de la cada del muro de Berln)
GLP-1, substance P, and BNP, commonly show a vasodilation effect, while NPY has a significant hypertensive effect
In addition, they may help support weight management without the use of GLP-1 receptor agonist medications and the concern of their common side effects.
And the spray tool allows for alternative administration routes and bioavailability comparisons
GLP-1R agonists show great potential in AD, but key challenges, such as blood brain barrier (BBB) penetration, clinical trial inconsistency, long-term safety and precision therapy, need to be addressed