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Despite the similarly large decreases in body weight, the Sema group showed significant lean mass loss compared to the control group during the 4-week treatment period, while the Sema + -MSTN/-ActA group was not only protected against this lean mass loss, but also had a significant increase in lean mass (Fig

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4 show the liraglutide concentration in the different brain regions at 1 h after IV (5 mg/kg) or 12 h after SC (500 mg/kg) injections in rats

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