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While ETC is the source of superoxide, the existence of mitochondrial NO synthase (mtNOS) that provides the NO required to form peroxynitrite is controversial
Ma et al., 2018), but its effects on PI3K/AKT, NRF2, and other pathways are not consistent
The administration of hemin results in the boost of HO-1 expression and mitigates inflammatory responses in retinal ganglion cell injury in diabetic retinopathy, as well as diabetic wound healing, diabetic kidney function and [54,55,56]
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However, this "renewal" process can sometimes be aggressive
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