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People taking metformin Metformin, commonly prescribed for type 2 diabetes, is independently associated with reduced B12 absorption
European Medicines Agency
Heres what we know and dont know: Most cases were described as mild and did not lead to stopping the drug Its not seen with semaglutide or tirzepatide it may be related to glucagon receptor activation, but this isnt confirmed The Phase 2 trial did note altered or enhanced skin sensation at lower rates, so it may not be entirely new just more apparent at scale It needs investigation across the remaining 7 Phase 3 trials reporting in 2026 Is it a dealbreaker
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Do not take the drug out of the original carton to avoid unnecessary exposure to light and heat
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