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Because B12 is water-soluble, your body uses what it needs for immediate metabolic tasks and stores a portion in the liver

When to reassess If GI symptoms worsen instead of improving over the first 2-3 weeks of a step, if dysesthesia appears suddenly, or if you cannot keep food down, pause and consult a qualified clinician

If you have or ever had pancreatitis, diabetic retinopathy or any kidney disease make sure your doctor knows about it

Bruijn N, van Lohuizen R, Boron M, Fitzek M, Gabriele F, Giuliani G et al (2024) Influence of metabolic state and body composition on the action of pharmacological treatment of migraine

Side-effects were similar between the two groups, though those on liraglutide did experience more gastrointestinal symptoms