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In rodents, this effect likely occurs through a calcitonin-dependent pathway since GLP-1 does not appear to have a direct effect on osteoblasts and osteoclasts in vitro [56]
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Retatrutide appears more aggressive mechanistically because it activates three receptor pathways
It acts as a key transporter of long-chain fatty acids into mitochondria, where these fats are oxidized to produce adenosine triphosphate (ATP), the cells energy currency
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