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All GLP-1 RAs are eliminated mainly via proteolytic degradation (not renal clearance, except exenatide which has some renal excretion)

FDA approval of EGRIFTA WR (tesamorelin F8) for excess visceral abdominal fat in adults with HIV and lipodystrophy

To ultimately tease apart any possible cause from secondary events, species-specific biology will also need to be carefully dissected and interpreted

But the body doesn't operate in an ideal scenario when the caloric deficit is steep