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Practical requirements: Hydration, ketone monitoring, sick-day rules, and clear stop rules are non-negotiable
Metformin increases lipolysis in cells, but only post-reduction in ROS and UCP2 levels
A cross-sectional and longitudinal study using LC-MS and non-targeted metabolomics reported that citrulline showed lower relative concentrations in individuals with metformin-treated T2D individuals compared to those without metformin treatment in the human study
These can disrupt gut microbiota and digestion
DOI: 10.1371 61
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