In addiction treatment settings specifically, patients have generally tolerated the medications well, and clinicians have reported no unexpected or severe adverse effects
Controlled human data on weight loss for this combination is limited, and neither peptide is approved for weight loss
Exclusion criteria included other forms of diabetes mellitus, pregnancy or lactation, contraindications to GLP-1RAs, previous or ongoing treatment with pioglitazone and/or Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and/or GLP-1RAs, inadequate ability to comply with follow-up or provide informed consent, implantable electronic devices (cardioverter defibrillators or pacemakers) contraindicating body composition assessment by segmental multifrequency bioelectrical impedance analysis (SMF-BIA- Seca mBCA 525), as indicated by the manufacturer (Seca GmbH & Co., KG, Hamburg, Germany), the use of oral contraceptives or corticosteroids, infection by viral hepatitis B and C, and excessive ethanol consumption (more than 30 grams/day in men and 20 grams/day in women)
Today 34 (10), 721735
Pricing is flat and does not increase as doses change
