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They are collectively classified as proteopathies, which involve severe disruption in cellular protein homeostasis (proteostasis) associated with protein misfolding as well as disruptions in protein processing and localization (Chowhan et al., 2015)
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On the one hand, p53 can promote ferroptosis by inhibiting the expression of SLC7A11 (39)
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Its neuroregulatory effects on the hypothalamus and GABAergic systems further contribute to improved overall sleep quality (2)
