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3.1 Clinical studies of ferroptosis in neurodegenerative diseases Human biospecimen analyses revealed elevated agrin expression, reduced levels of platelet-derived growth factor receptor beta (PDGFR), type IV collagen, and fibronectin, pronounced small artery atherosclerosis and venous collagen deposition, and a reduction in pericyte numbers in the brain tissue of AD patients

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It is structurally distinct from IGF-1 LR3 and acts through what some researchers describe as an MGF-specific receptor pathway, although the precise receptor identification remains debated in the published literature