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They can be influenced by a wide array of factors, including (12,13): Hormonal Imbalances: Issues with thyroid hormones, cortisol (the stress hormone), or sex hormones can significantly impact metabolism

The enzymes that normally eliminate radical oxygen species are especially vulnerable

Despite this limitation, there is significant consumer demand for these drugs beyond their approved uses

As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk (Vilhardt et al., 2017)

Glutathione is most commonly found in the human liver and is composed of three amino acids: glycine, cysteine, and glutamic acid