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Increased DPP4 expression in the liver positively correlates with the degree of steatosis and NAFLD (20, 21)

B12 deficiency can cause: If you have anaemia caused by a vitamin B12 deficiency, you may have other symptoms, such as: Some of these symptoms can also happen in people who have a vitamin B12 deficiency but have not developed anaemia

Also, these effects can be attributed to direct action on GLP-1R in cardiac and vascular tissues [50]

Treatment challenges are substantial and multifaceted

Methotrexate, on the other hand, reduces protective antioxidants like glutathione (GSH) and inhibits enzymes that scavenge free radicals, causing the liver to become more susceptible to damage (Goudarzi et al