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ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss

Succinate Dehydrogenase (SDH): The multi-enzyme complex called succinate dehydrogenase (SDH) catalyzes the oxidation of succinate to fumarate with the sequential reduction of enzyme-bound FAD to FADH 2 as well as the associated non-heme-iron

At the molecular level, the compound is modeled after liraglutide - a GLP-1 analog designed with a lysine-to-arginine substitution at position 34

The resulting neuroexcitoxicity may be responsible for chronic hyperalgesia

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