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Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways
By increasing Nrf2 downregulation and enhancing ROS generation, parthenolide (PN) and its soluble counterpart dimethyl amino parthenolide (DMPN) have been demonstrated to diminish mammosphere development in triple-negative breast cancer (TNBC) cell lines, as well as the survival of mammosphere-derived CSCs, most likely through increased ubiquitination and proteasome degradation (Carlisi et al., 2016)
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doi: 10.26355/eurrev_202004_20985 267 FuXSongGNiRLiuHXuZZhangDet al
One of the key aspects of diagnosing this disorder, aside from having a clinical suspicion in the setting of anion gap metabolic acidosis without another explanation, is the detection of 5-oxoproline in the urine
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