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There is limited long-term safety data, and several regulators have warned about injectable skin-lightening products
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Obesity, particularly in those with android body fat distribution, are at increased risk of NAFLD and disease progression and individuals with complications such as hypertension, knee osteoarthritis, or sleep apnea should also be screened for advanced liver disease
Many persons with oral mucosal melanin hyperpigmentation are unaware of its presence [7]
This angiogenic effect has been documented in models of tendon healing, muscle repair, bone fracture recovery, and skin wound closure
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