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At the same time, activation of the polyol pathway also depletes large amounts of nicotinamide adenine dinucleotide phosphate (NADPH) and GSH synthesis, which further weakens cellular antioxidant capacity and exacerbates the extent of OS ( The protein kinase C (PKC) pathway is also activated in response to OS

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Understanding which mechanism dominates your particular reaction pattern determines which treatment and prevention strategy will work best

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These trials tracked numerous safety parameters and laboratory values, but vitamin b12 levels were not routinely monitored or reported in the published results

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