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The first 4 to 8 weeks are usually a dose-escalation phase at lower, "starter" doses designed to allow the body to adjust to side effects like nausea

Advanced disease models, including genetically stratified organoids, patient-derived iPSC lines, and age-appropriate 3D brain cultures, may offer more refined platforms to dissect these differences and identify compound-subtype associations (Sirkis et al., 2022)