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Contact Us Promptly If You Notice: Significant swelling, warmth, or hardness at the injection site that worsens after 48 hours rather than improving this can indicate a localized infection A spreading rash, hives, or itching that moves beyond the injection site Shortness of breath, chest tightness, or facial swelling these require immediate attention and a call to 911, not just the spa Intense or persistent nausea and vomiting that does not resolve within a day Numbness, tingling, or palpitations These are not common presentations, but they are the signals the body uses to say something needs attention

This barrier severely restricts drug delivery and prevents potentially effective central nervous system treatments from being used clinically [112]

Statements Data availability statement Data in this manuscript were collected and managed in accordance with the data management policy of the FLI

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In addition, using syringes may also increase the risk of infections