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How Does Retatrutide Work in the Body

Clinical studies have shown that tirzepatide can lead to significant weight loss in adults with obesity or overweight, even in people without diabetes

None of the funders were involved in the design of the study

Dallman et al., 2005

How treatment is chosen: the modern algorithm Current NICE NG28 (and the ADA Standards of Care) personalise the second drug to the person, not just the HbA1c: Established cardiovascular disease, heart failure, or chronic kidney disease SGLT2 inhibitor first add-on (or first-line alongside metformin)