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doi: 10.1111/imr.13157 131 LiuLDasSLosertWParentCA
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In addition, pro-inflammatory cytokines can act to steal tryptophan away from serotonin and melatonin pathways (via up-regulation of the enzymes IDO and TDO), increasing the activity of the NMDA agonist quinolinic acid, and further antagonising stimulation of NMDA pathways, which subsequently exacerbates mood and sleep issues
Subsequent human studies including the 2016 Lee et al
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