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Additionally, folate-mediated one-carbon metabolism, closely linked to glutamine availability, is essential for nucleotide synthesis and redox balance via NADPH production [7, 49]

Early pharmacokinetic studies suggested that when standard, unprotected glutathione was ingested, it was rapidly cleaved into its constituent amino acids (glutamate, cysteine, and glycine) by digestive enzymes like $\gamma$-glutamyltransferase and harsh stomach acids

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