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Spichak, S
10.1530/eje.1.02221 73
This dual-agonism activity of tirzepatide may contribute to the greater weight reduction observed with tirzepatide than with semaglutide, a monoagonist used in the current trial. The results show that as weight reduction increased there were greater improvements in cardiometabolic risk factors, including blood pressure, and blood fat and sugar levels, with both treatments consistent with previous reports
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Both sexes showed impaired glucose metabolism and delayed glucose clearance, and liver function analyses revealed elevated alanine aminotransferase (ALT) levels, especially in female rats consuming EDs, consistent with hepatocellular damage
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