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Diabetic Retinopathy Diabetic retinopathy (DR) is associated with dysregulation of the BRB, driven primarily by the upregulation of VEGF, which disrupts endothelial TJs [156]

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First, during the Phase I , known as activation, specialized enzymesparticularly those of the cytochrome P450 familymodify the chemical structure of toxins to prepare them for Phase II

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