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Skin improvements typically begin within 48 weeks, with significant and more profound changes observed after 12+ weeks of consistent use
Adhikari R, Jha K, Dardari Z et al (2015) National trends in use of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists by cardiologists and other specialties, 2015 to 2020
This sequence of events is similar to what you'd see from competitors
Summary: The retatrutide phase 2 NEJM trial reported mean body weight reductions of up to approximately 24.2% at 48 weeks with the 12 mg dose in adults with obesity without type 2 diabetes
Gastric Bypass: A Proven Option for Significant, Lasting Weight Loss For patients with a higher BMI, existing conditions like type 2 diabetes, or a history of regaining weight after previous attempts, gastric bypass is often the more effective long-term option
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