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Warnings and Precautions 5.1 Risk of Thyroid C-Cell Tumors In both sexes of rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]

Certain organ diseases and especially tumors are associated with the occurrence of this pathological manifestation

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Research has also linked choline deficiencies to nonalcoholic fatty liver disease [8]

Treatment of traumatic brain injury with thymosin 4 in rats