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Furthermore, ACSL4 can drive neuronal death by amplifying neuronal ferroptosis [46]
Unless otherwise stated, experiments containing yeast peptides were searched using the yeast phosphopeptide library, those containing human peptides using the human phosphopeptide library, and those containing both with both
Indeed, while efficiently inducing ferroptosis in different tumor cell lines, RSL3 and ML162 were found to also acts on TXRND1, an important detoxifying enzyme whose inhibition can also trigger apoptosis and/or ferroptosis [51, 52]
Reference: Gwyer D, Wragg NM, Wilson SL (2019)
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