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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
Abstract 4366: Loss of EP300 triggers IL-1 signaling and subsequent activation of the IL-6/JAK/STAT3 axis to drive oncogenesis in bladder cancer
Dig Dis Sci (1989) 34(9):14119
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Raun K et al., Eur J Endocrinol, 1998 139(5):552-561
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