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Interestingly, however, common responses to GLP1/E were observed in both PCOS models, with upregulation of hypothalamic pathways involved in autophagy and vesicle-mediated transport, and downregulation of pathways primarily related to the immune system

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DOI: Published online: October 15, 2025 1 Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan 3 Kurinami Clinic, Kanzaki, Kumamoto, Japan 4 Division of Cardiovascular Medicine, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan 5 Division of Preventive Cardiology, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan Corresponding author: Hideaki Jinnouchi