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miRNAs like miR-148a and miR-340 regulate pigmentation by modulating MITF and dendrite formation, while miR-21 enhances anti-apoptotic and proliferative pathways in melanocytes post-UVA exposure, indicating multifaceted roles in pigmentation and survival 104,105
For example, in CAMKIIalpha-driven GPX4 knockout (KO) mice, mitochondrial dysfunction and ferroptosis due to chelated lipid peroxidation caused mice to display spinal motor neuron degeneration, paralysis, and death within 8 days of knockout (34), suggesting that cellular ferroptosis can be affected by regulating GPX4
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The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells
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