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RF and EP contributed with clinical measurements
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease
This vulnerability has been targeted in therapies with GPX4 inhibitors or iron modifiers in order to increase lipid peroxidation and preferentially kill cancer cells
Common side effects include injection site reactions such as redness, swelling, or discomfort, temporary nausea, occasional headaches, and fatigue in some users
Activation of AMPK2 attenuated doxorubicin-induced cardiotoxicity via inhibiting lipid peroxidation associated ferroptosis
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