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Two-tailed Students t-tests (for age of the study participants, age at menarche, years since menarche, and duration of menstrual bleeding), Fishers exact tests (for smoking status), and Chi square (for ethnicity, occupational status, and menstrual cycle stage) were used to compare Cases and Controls

NAD+ Supplementation attenuates methylmercury dopaminergic and mitochondrial toxicity in Caenorhabditis elegans

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certificate of analysis available on request Research Applications Suitable Laboratory Uses for FOXO4-DRI FOXO4-p53 protein-protein interaction disruption assays CO-IP, competitive binding, and proximity ligation studies Selective senescent cell apoptosis induction SA--gal, p16, p21, p53 marker-confirmed senescent populations p53 TAD2 binding, phospho-p53 (Ser15) nuclear exclusion, and mitochondrial translocation pathway studies BAX/BCL-2/Caspase-3 intrinsic apoptosis cascade investigations in senescent cell models SASP characterisation and suppression IL-6, IL-8, MMP, VEGF, CXCL2/3 secretome studies Tissue-specific senescence models fibroblasts, endothelial cells, Leydig cells, chondrocytes, keloid fibroblasts Vascular ageing pathway research endothelial senescence, aortic function, and ROS pathway studies Senescent cancer cell biology and drug resistance pathway research Comparative senolytic research FOXO4-DRI vs

Conceptualization, Formal Analysis, Investigation, Visualization, Writing-original draft, Writing-review & editing Y.L