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Although no medication is specifically approved to treat IR, we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity

A randomized, double-blind, controlled phase II trial in advanced renal cell carcinoma (RCC) demonstrated synergistic anticancer effects with the combination of the glutaminase inhibitor telaglenastat (CB-839) and the mTOR inhibitor everolimus (TelaE), which was well tolerated by patients previously treated with TKIs

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Unknown Risks: Given its influence on fundamental metabolic processes (AMPK) and mTOR regulation, the long-term safety of chronic, supraphysiological MOTS-c administration is unknown and requires caution