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I had the same reaction with all 3 injection sites

The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

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Injection site redness may appear and resolve within 24 to 48 hours

Infection risk: Though the benzyl alcohol preservative inhibits bacterial growth in the vial, any lapse in sterility (dirty needle, etc.) can introduce pathogens