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TILs, particularly cytotoxic CD8+ and Th1-type CD4+ T cells, have shown improved prognosis and therapeutic response, especially in TNBC and HER2-positive breast malignancies

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Wouters, School of Medicine, Faculty of Health, Deakin University, Geelong, VIC 3216, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

Additionally, NADH can be generated by fatty acid oxidation (FAO) in the cytoplasm in tissues with high energy demand, such as cardiac muscle tissues, as well as in cancer cells 141

doi: 10.1016/j.ejps.2022.106246 64 AnsariPReberioADAnsariNJKumarSKhanJTChowdhurySet al