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Furthermore, a prespecified subgroup analysis of HF individuals from the SELECT trial evaluating the effects of semaglutide on cardiovascular outcomes in people with overweight or obesity, which included 2,273 HFpEF and 1,347 HFrEF patients, showed that the therapy was associated with a reduction in the HF composite outcome (cardiovascular death or HF hospitalisation/emergency visit) across LVEF, suggesting that GLP-1 RAs may improve outcomes at least in obese HF patients regardless of diabetes status
RANK also serves as an activator of the nuclear factor B (NF-B) receptor, which is likewise involved in osteoclast differentiation (55)
Being untested in a population is not the same as being shown safe in it
GLP-1 therapy is changing the game in the prevention and treatment of many chronic conditions
Amato, A
