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Related article: Glutathione synthesis and genetic variants Once a toxic substance has been conjugated with glutathione via the GST-specific enzyme, the body excretes it via bile or urine

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A randomized controlled trial found that atomoxetine (a pure NET inhibitor) significantly increased standing heart rate from 105 to 121 bpm and worsened symptom scores in POTS patients (Green et al., JAHA , 2013

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That flexibility is uncommon among peptides