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In this mouse model, 7585% decrease of Gpx4 was shown to induce hippocampal neuronal loss, lipid peroxidation, neuroinflammation and spatial learning deficits ( Gpx1 , facilitated memory impairment induced by -Amyloid in mice ( Oxidative Stress and Lipid Peroxidation The brain is the most vulnerable organ to oxidative stress
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This is consistent with the fact that examination of the fatty-acid oxidation pathway in fibroblast culture did not reveal any abnormalities to explain the elevations in acyl-carnitines
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