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doi: 10.3389/FPHAR.2025.1517272/FULL 129 BonfioliGBRodellaLMetraMVizzardiE

3.1.1.4 Grape seed proanthocyanidin extract (GSPE) GSPE, a natural bioactive compound from plant, exhibits great therapeutic properties through inhibiting oxidative stress and promoting mitochondrial biogenesis ( via AMPK-Sirtuin-1-PGC-1-TFAM signaling pathway ( 3.1.2 Sirtuin activators 3.1.2.1 Resveratrol Resveratrol, a natural compound extracted from the berries of Vaccinium species, can activate sirtuin-1, sirtuin-3, and sirtuin-5 (Xia et al., 2017

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To help overcome this, the researchers performed a subgroup analysis of specific characteristics shared by individuals within the pooled studies

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