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If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered

Gastrointestinal Reactions (Reported/Theoretical) : Some reports suggest possible nausea or digestive discomfort, although consistent human data are lacking

a sequence of 15 amino acids) derived from a protective protein naturally found in human gastric juice

With continued research on necrosis, investigators have divided the process into necroptosis and pyroptosis [105]

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