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Among the 42, there are only two pairs of charged residues: (a) B LYS 26 of semaglutide and A GLU 128 of GLP-1R ECD

While most clinicians think of these agents for glucose lowering and weight loss, growing evidence suggests they may also support better blood pressure control

Acknowledgements This work was supported by a Basic Science Research Program grant of the National Research Foundation of Korea, the Ministry of Education of Korea (2017R1D1A1B03036210 to JHL), American Heart Association Grant 14GRNT18990019 (YS), and American Diabetes Association Award #1-15-BS-177 (YS)

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