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The antibody Fab7F38 appears to function by providing enhanced soluble surface area for crystal lattice packing, and indeed Fab7F38-bound GLP-1R can also assume an active conformation as shown by EM studies (see below), suggesting that Fab7F38 does not interfere with the conformational flexibility of the ECD during crystallization

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It is also reported that L-carnitine supplementation can improve the glycemic status and related indices by changing the expression of genes related to glycolytic and gluconeogenic enzymes, modulating the activity of the pyruvate dehydrogenase enzyme complex, and changing the expression of genes involved in insulin metabolism (94, 95)