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MOTS-c is a short peptide (16 amino acids), which makes it relatively resistant to the enzymatic degradation that degrades larger peptides, but also means that reconstitution technique and storage conditions matter considerably

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It has been shown to ameliorate oxaliplatin-induced peripheral neuropathy in rats and effectively attenuate oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells without impairing anticancer efficacy, in which donepezil recovered oxaliplatin-induced reduction in SOD activity and exerted antioxidant effects [166]

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