In obese animal models with suppressed beta-3 receptor levels, treatment restored receptor expression to levels comparable to lean controls
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While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear ( in vitro using glutathione disulfide (GSSG) or in vivo in response to ozone and paraquat, and inactivated upon reduction ( Four APK proteins exist in Arabidopsis, APK1, 2, and 4 locate in plastids whereas APK3 is in the cytosol (Mugford et al., 2009)
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Its chemical structure, characterized by a planar 3,4,5,7-tetrahydroxyflavone scaffold, confers strong antioxidant, anti-inflammatory, anti-fibrotic, and metabolic-regulatory properties (Hasnat et al., 2024