Adaptive response to GSH depletion and resistance to l-buthionine-( S , R )-sulfoximine: involvement of Nrf2 activation
Under glucose-rich conditions, the polymerase-associated factor 1 complex (Paf1C) can maintain low levels of mitophagy by binding to the promoter of the Atg32 gene, while upon starvation, Paf1C dissociates from Atg32 , resulting in increased expression of the Atg32 gene and induction of mitophagy [197]
When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2
As depicted in Figure 4, unscavenged superoxide inactivates aconitase by displacing Fe +2 from the Fe-S cluster, which then promotes the formation of the damaging hydroxyl radical via reaction with H 2 O 2 and Fenton chemistry
Claves de su funcionamiento El glutatin es conocido como el principal desintoxicante de nuestro cuerpo y constantemente procesa y elimina toxinas a travs de la va de desintoxicacin de fase II