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2020;15(9):e0239843
Treatment reinitiation Among those who discontinued a GLP-1 receptor agonist, the cumulative incidence of reinitiating treatment was 41.1% (95% CI 40.5, 41.7) at 1 year and 57.4% (95% CI 56.7, 58.1) at 3 years when using a grace period of 90 days in the definition of treatment discontinuation (Fig
In the ACHIEVE-1 trial for type 2 diabetes, patients on the highest dose of orforglipron (36 mg daily) achieved an average A1C reduction of approximately 1.6% and lost around 9.4% of their body weight over 40 weeks
Shahid W, Satyjeet F, Kumari R, et al
The brain's ability to utilize glucose becomes measurably impaired, creating an energetic deficit at the neuronal level
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